Tennessee Titans vs San Francisco 49ers - NFL Prediction (2025-12-14)

Tennessee Titans vs. San Francisco 49ers: Game Breakdown

Matchup details

• Teams: Tennessee Titans vs. San Francisco 49ers
• Date: loading...
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Betting insights

Spread: Tennessee Titans favored at -11.45. Total: 44.01.

Game prediction summary

Tennessee Titans and San Francisco 49ers face off on loading..., loading..., in a matchup that's drawn attention from bettors and fans alike.

We're projecting a final score of Tennessee Titans 16 – 28 San Francisco 49ers, with win probabilities leaning 87% in favor of San Francisco 49ers. Current odds list the spread at -11.45, with the total set at 44.01.

Touchdown Scorer Predictions

For Anytime Touchdown Scorer bets, the top option from Tennessee Titans is Chimere Dike (the player with the highest anytime touchdown probability on the team at 24.6%). He is followed by Elic Ayomanor, who also poses a strong scoring threat with a 22.7% chance.

On the San Francisco 49ers side, Christian McCaffrey leads with the highest probability at 69.2% , while George Kittle follows closely at 39.3% .

For First Touchdown Scorer odds, our data again puts Chimere Dike (team-high 5.9% probability) as the most likely to score first for Tennessee Titans. Over on the San Francisco 49ers side, Christian McCaffrey ranks highest with a 21.1% chance to be the first touchdown scorer in the game.

Box Score Predictions

When box score data is available, we spotlight each team's leaders by projection. For Tennessee Titans, Tony Pollard (highest projected rusher on Tennessee Titans) is forecast for 45 rushing yards and 0.22 TDs , while Chimere Dike (highest projected receiver on Tennessee Titans) is pegged for 36 receiving yards and 0.25 TDs .

On San Francisco 49ers, Christian McCaffrey (highest projected rusher on San Francisco 49ers) leads the ground game with 73 yards and 0.69 TDs , and George Kittle (highest projected receiver on San Francisco 49ers) tops the passing attack with 57 yards and 0.39 TDs .

All stat lines are simulation-driven and update as new information becomes available.

Responsible betting

Sports betting should always be fun - a form of entertainment, not a way to solve financial problems. If you're finding that betting is causing stress or impacting your budget, take a step back. Never wager more than you can afford to lose.

Your mental well-being matters. Chasing losses or trying to "win it all back" is a warning sign. If friends or family raise concerns, take them seriously - they're often the first to notice when something's wrong.

If betting no longer feels like a choice or if it's affecting your life in a negative way, help is available. Visit Gambling Therapy for free, confidential support. Their trained advisors are available 24/7, and you'll also find peer support groups to talk with others who understand what you're going through.

Bet smart. Stay in control. Your well-being comes first.