San Francisco 49ers vs Tampa Bay Buccaneers - NFL Prediction (2025-10-12)

San Francisco 49ers vs. Tampa Bay Buccaneers: Game Breakdown

Matchup details

• Teams: San Francisco 49ers vs. Tampa Bay Buccaneers
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Betting insights

Spread: San Francisco 49ers favored at -2.52. Total: 46.77.

Game prediction summary

San Francisco 49ers and Tampa Bay Buccaneers face off on loading..., loading..., in a matchup that's drawn attention from bettors and fans alike.

We're projecting a final score of San Francisco 49ers 22 – 25 Tampa Bay Buccaneers, with win probabilities leaning 59% in favor of Tampa Bay Buccaneers. Current odds list the spread at -2.52, with the total set at 46.77.

Touchdown Scorer Predictions

For Anytime Touchdown Scorer bets, the top option from San Francisco 49ers is Christian McCaffrey (the player with the highest anytime touchdown probability on the team at 55.8%). He is followed by Jauan Jennings, who also poses a strong scoring threat with a 28.5% chance.

On the Tampa Bay Buccaneers side, Rachaad White leads with the highest probability at 54.9% , while Emeka Egbuka follows closely at 44.4% .

For First Touchdown Scorer odds, our data again puts Christian McCaffrey (team-high 11.9% probability) as the most likely to score first for San Francisco 49ers. Over on the Tampa Bay Buccaneers side, Rachaad White ranks highest with a 13.7% chance to be the first touchdown scorer in the game.

Box Score Predictions

When box score data is available, we spotlight each team's leaders by projection. For San Francisco 49ers, Christian McCaffrey (highest projected rusher on San Francisco 49ers) is forecast for 69 rushing yards and 0.56 TDs , while Christian McCaffrey (highest projected receiver on San Francisco 49ers) is pegged for 50 receiving yards and 0.56 TDs .

On Tampa Bay Buccaneers, Rachaad White (highest projected rusher on Tampa Bay Buccaneers) leads the ground game with 61 yards and 0.56 TDs , and Emeka Egbuka (highest projected receiver on Tampa Bay Buccaneers) tops the passing attack with 83 yards and 0.48 TDs .

All stat lines are simulation-driven and update as new information becomes available.

Responsible betting

Sports betting should always be fun - a form of entertainment, not a way to solve financial problems. If you're finding that betting is causing stress or impacting your budget, take a step back. Never wager more than you can afford to lose.

Your mental well-being matters. Chasing losses or trying to "win it all back" is a warning sign. If friends or family raise concerns, take them seriously - they're often the first to notice when something's wrong.

If betting no longer feels like a choice or if it's affecting your life in a negative way, help is available. Visit Gambling Therapy for free, confidential support. Their trained advisors are available 24/7, and you'll also find peer support groups to talk with others who understand what you're going through.

Bet smart. Stay in control. Your well-being comes first.