Indianapolis Colts vs Tennessee Titans - NFL Prediction (2025-09-21)

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Indianapolis Colts
vs
Tennessee Titans

Win probabilities

Indianapolis Colts
67%
Tennessee Titans
33%

Predicted score

24 - 20
Spread (Team 1 - Team 2): 4.38
Projected total: 43.65

Fair odds (decimal)

Indianapolis Colts: 1.49
Tennessee Titans: 3.03

Canadian Moneyline Odds

Indianapolis Colts
-208
Tennessee Titans
+165
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Anytime Touchdown Probability

Indianapolis Colts
  • Jonathan Taylor RB57.0%
  • Tyler Warren TE27.0%
  • Josh Downs WR22.4%
  • Michael Pittman WR22.1%
  • Daniel Jones QB21.7%
  • Alec Pierce WR14.9%
  • DJ Giddens RB9.8%
  • Adonai Mitchell WR5.4%
  • Tyler Goodson RB3.1%
  • Mo Alie-Cox TE3.1%
  • Drew Ogletree TE2.4%
  • Ashton Dulin WR1.2%
  • Anthony Gould WR0.2%
  • Will Mallory TE0.1%
Tennessee Titans
  • Tony Pollard RB41.8%
  • Calvin Ridley WR30.2%
  • Elic Ayomanor WR28.9%
  • Chig Okonkwo TE19.9%
  • Chimere Dike WR14.0%
  • Tyler Lockett WR14.0%
  • Cam Ward QB11.7%
  • Gunnar Helm TE6.0%
  • Van Jefferson WR5.1%
  • Julius Chestnut RB3.2%
  • Kalel Mullings RB2.4%

First Touchdown Probability

Indianapolis Colts
  • Jonathan Taylor RB18.1%
  • Tyler Warren TE6.8%
  • Josh Downs WR5.4%
  • Michael Pittman WR5.4%
  • Daniel Jones QB5.2%
  • Alec Pierce WR3.5%
  • DJ Giddens RB2.2%
  • Adonai Mitchell WR1.2%
  • Tyler Goodson RB0.7%
  • Mo Alie-Cox TE0.7%
  • Drew Ogletree TE0.5%
  • Ashton Dulin WR0.3%
  • Anthony Gould WR0.0%
  • Will Mallory TE0.0%
Tennessee Titans
  • Tony Pollard RB11.4%
  • Calvin Ridley WR7.6%
  • Elic Ayomanor WR7.2%
  • Chig Okonkwo TE4.7%
  • Chimere Dike WR3.2%
  • Tyler Lockett WR3.2%
  • Cam Ward QB2.6%
  • Gunnar Helm TE1.3%
  • Van Jefferson WR1.1%
  • Julius Chestnut RB0.7%
  • Kalel Mullings RB0.5%

Projected Indianapolis Colts Boxscore

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Projected Tennessee Titans Boxscore

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Indianapolis Colts vs. Tennessee Titans: Game Breakdown

Matchup details

  • Teams: Indianapolis Colts vs. Tennessee Titans
  • Date: loading...
  • Time: loading...

Betting insights

Spread: Tennessee Titans favored at -4.38. Total: 43.65.

Game prediction summary

Indianapolis Colts and Tennessee Titans face off on loading..., loading..., in a matchup that's drawn attention from bettors and fans alike.

We're projecting a final score of Indianapolis Colts 24 – 20 Tennessee Titans, with win probabilities leaning 67% in favor of Indianapolis Colts. Current odds list the spread at -4.38, with the total set at 43.65.

Touchdown Scorer Predictions

For Anytime Touchdown Scorer bets, the top option from Indianapolis Colts is Jonathan Taylor (the player with the highest anytime touchdown probability on the team at 57.0%). He is followed by Tyler Warren, who also poses a strong scoring threat with a 27.0% chance.

On the Tennessee Titans side, Tony Pollard leads with the highest probability at 41.8% , while Calvin Ridley follows closely at 30.2% .

For First Touchdown Scorer odds, our data again puts Jonathan Taylor (team-high 18.1% probability) as the most likely to score first for Indianapolis Colts. Over on the Tennessee Titans side, Tony Pollard ranks highest with a 11.4% chance to be the first touchdown scorer in the game.

Box Score Predictions

When box score data is available, we spotlight each team's leaders by projection. For Indianapolis Colts, Jonathan Taylor (highest projected rusher on Indianapolis Colts) is forecast for 87 rushing yards and 0.57 TDs , while Tyler Warren (highest projected receiver on Indianapolis Colts) is pegged for 51 receiving yards and 0.27 TDs .

On Tennessee Titans, Tony Pollard (highest projected rusher on Tennessee Titans) leads the ground game with 79 yards and 0.42 TDs , and Calvin Ridley (highest projected receiver on Tennessee Titans) tops the passing attack with 55 yards and 0.30 TDs .

All stat lines are simulation-driven and update as new information becomes available.

Responsible betting

Sports betting should always be fun - a form of entertainment, not a way to solve financial problems. If you're finding that betting is causing stress or impacting your budget, take a step back. Never wager more than you can afford to lose.

Your mental well-being matters. Chasing losses or trying to "win it all back" is a warning sign. If friends or family raise concerns, take them seriously - they're often the first to notice when something's wrong.

If betting no longer feels like a choice or if it's affecting your life in a negative way, help is available. Visit Gambling Therapy for free, confidential support. Their trained advisors are available 24/7, and you'll also find peer support groups to talk with others who understand what you're going through.

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