Carolina Panthers vs San Francisco 49ers - NFL Prediction (2025-11-25)

Carolina Panthers vs. San Francisco 49ers: Game Breakdown

Matchup details

• Teams: Carolina Panthers vs. San Francisco 49ers
• Date: loading...
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Betting insights

Spread: Carolina Panthers favored at -6.26. Total: 46.10.

Game prediction summary

Carolina Panthers and San Francisco 49ers face off on loading..., loading..., in a matchup that's drawn attention from bettors and fans alike.

We're projecting a final score of Carolina Panthers 20 – 26 San Francisco 49ers, with win probabilities leaning 72% in favor of San Francisco 49ers. Current odds list the spread at -6.26, with the total set at 46.10.

Responsible betting

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