Buffalo Bills vs New England Patriots - NFL Prediction (2025-12-14)

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Buffalo Bills
vs
New England Patriots

Win probabilities

Buffalo Bills
57%
New England Patriots
43%

Predicted score

25 - 23
Spread (Team 1 - Team 2): 1.95
Projected total: 48.87

Fair odds (decimal)

Buffalo Bills: 1.75
New England Patriots: 2.33

Canadian Moneyline Odds

Buffalo Bills
-122
New England Patriots
-105
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Anytime Touchdown Probability

Buffalo Bills
  • James Cook RB51.2%
  • Josh Allen QB46.5%
  • Khalil Shakir WR28.8%
  • Dalton Kincaid TE26.5%
  • Dawson Knox TE17.8%
  • Gabe Davis WR17.7%
  • Ty Johnson RB17.7%
  • Keon Coleman WR16.6%
  • Joshua Palmer WR11.5%
  • Tyrell Shavers WR11.4%
  • Ray Davis RB9.1%
  • Jackson Hawes TE8.0%
  • Brandin Cooks WR6.6%
New England Patriots
  • TreVeyon Henderson RB48.0%
  • Stefon Diggs WR35.0%
  • Hunter Henry TE29.2%
  • Rhamondre Stevenson RB28.4%
  • Kayshon Boutte WR25.7%
  • Drake Maye QB21.3%
  • Mack Hollins WR21.0%
  • DeMario Douglas WR13.5%
  • Austin Hooper TE8.8%
  • Kyle Williams WR7.0%
  • Efton Chism WR5.2%
  • Terrell Jennings RB4.3%
  • D'Ernest Johnson RB0.4%

First Touchdown Probability

Buffalo Bills
  • James Cook RB10.3%
  • Josh Allen QB9.0%
  • Khalil Shakir WR4.9%
  • Dalton Kincaid TE4.4%
  • Dawson Knox TE2.8%
  • Gabe Davis WR2.8%
  • Ty Johnson RB2.8%
  • Keon Coleman WR2.6%
  • Joshua Palmer WR1.8%
  • Tyrell Shavers WR1.7%
  • Ray Davis RB1.4%
  • Jackson Hawes TE1.2%
  • Brandin Cooks WR1.0%
New England Patriots
  • TreVeyon Henderson RB9.9%
  • Stefon Diggs WR6.5%
  • Hunter Henry TE5.2%
  • Rhamondre Stevenson RB5.1%
  • Kayshon Boutte WR4.5%
  • Drake Maye QB3.6%
  • Mack Hollins WR3.6%
  • DeMario Douglas WR2.2%
  • Austin Hooper TE1.4%
  • Kyle Williams WR1.1%
  • Efton Chism WR0.8%
  • Terrell Jennings RB0.7%
  • D'Ernest Johnson RB0.1%

Projected Buffalo Bills Boxscore

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Projected New England Patriots Boxscore

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Buffalo Bills vs. New England Patriots: Game Breakdown

Matchup details

  • Teams: Buffalo Bills vs. New England Patriots
  • Date: loading...
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Betting insights

Spread: New England Patriots favored at -1.95. Total: 48.87.

Game prediction summary

Buffalo Bills and New England Patriots face off on loading..., loading..., in a matchup that's drawn attention from bettors and fans alike.

We're projecting a final score of Buffalo Bills 25 – 23 New England Patriots, with win probabilities leaning 57% in favor of Buffalo Bills. Current odds list the spread at -1.95, with the total set at 48.87.

Touchdown Scorer Predictions

For Anytime Touchdown Scorer bets, the top option from Buffalo Bills is James Cook (the player with the highest anytime touchdown probability on the team at 51.2%). He is followed by Josh Allen, who also poses a strong scoring threat with a 46.5% chance.

On the New England Patriots side, TreVeyon Henderson leads with the highest probability at 48.0% , while Stefon Diggs follows closely at 35.0% .

For First Touchdown Scorer odds, our data again puts James Cook (team-high 10.3% probability) as the most likely to score first for Buffalo Bills. Over on the New England Patriots side, TreVeyon Henderson ranks highest with a 9.9% chance to be the first touchdown scorer in the game.

Box Score Predictions

When box score data is available, we spotlight each team's leaders by projection. For Buffalo Bills, James Cook (highest projected rusher on Buffalo Bills) is forecast for 88 rushing yards and 0.51 TDs , while Khalil Shakir (highest projected receiver on Buffalo Bills) is pegged for 49 receiving yards and 0.29 TDs .

On New England Patriots, TreVeyon Henderson (highest projected rusher on New England Patriots) leads the ground game with 48 yards and 0.48 TDs , and Stefon Diggs (highest projected receiver on New England Patriots) tops the passing attack with 57 yards and 0.35 TDs .

All stat lines are simulation-driven and update as new information becomes available.

Responsible betting

Sports betting should always be fun - a form of entertainment, not a way to solve financial problems. If you're finding that betting is causing stress or impacting your budget, take a step back. Never wager more than you can afford to lose.

Your mental well-being matters. Chasing losses or trying to "win it all back" is a warning sign. If friends or family raise concerns, take them seriously - they're often the first to notice when something's wrong.

If betting no longer feels like a choice or if it's affecting your life in a negative way, help is available. Visit Gambling Therapy for free, confidential support. Their trained advisors are available 24/7, and you'll also find peer support groups to talk with others who understand what you're going through.

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