Buffalo Bills vs Houston Texans - NFL Prediction (2025-11-21)
Win probabilities
Buffalo Bills Houston TexansPredicted score
Fair odds (decimal)
Canadian Moneyline Odds
Anytime Touchdown Probability
Buffalo Bills- James Cook RB51.8%
- Josh Allen QB49.7%
- Khalil Shakir WR27.2%
- Dawson Knox TE19.5%
- Keon Coleman WR19.4%
- Ty Johnson RB18.0%
- Gabe Davis WR17.5%
- Tyrell Shavers WR15.8%
- Joshua Palmer WR15.7%
- Curtis Samuel WR14.4%
- Jackson Hawes TE8.8%
- Elijah Moore WR6.4%
- Mecole Hardman WR6.3%
- Ray Davis RB5.8%
Houston Texans- Woody Marks RB42.7%
- Nico Collins WR36.9%
- Dalton Schultz TE19.9%
- Jayden Higgins WR18.0%
- Nick Chubb RB17.0%
- Christian Kirk WR11.8%
- Davis Mills QB8.6%
- Xavier Hutchinson WR8.6%
- Jaylin Noel WR7.7%
- Cade Stover TE5.5%
- Dare Ogunbowale RB3.7%
- Dameon Pierce RB2.5%
- Braxton Berrios WR1.9%
- British Brooks RB1.7%
First Touchdown Probability
Buffalo Bills- James Cook RB11.2%
- Josh Allen QB10.5%
- Khalil Shakir WR4.8%
- Dawson Knox TE3.3%
- Keon Coleman WR3.3%
- Ty Johnson RB3.0%
- Gabe Davis WR2.9%
- Tyrell Shavers WR2.6%
- Joshua Palmer WR2.6%
- Curtis Samuel WR2.4%
- Jackson Hawes TE1.4%
- Elijah Moore WR1.0%
- Mecole Hardman WR1.0%
- Ray Davis RB0.9%
Houston Texans- Woody Marks RB9.9%
- Nico Collins WR8.2%
- Dalton Schultz TE3.9%
- Jayden Higgins WR3.5%
- Nick Chubb RB3.3%
- Christian Kirk WR2.2%
- Davis Mills QB1.6%
- Xavier Hutchinson WR1.6%
- Jaylin Noel WR1.4%
- Cade Stover TE1.0%
- Dare Ogunbowale RB0.7%
- Dameon Pierce RB0.4%
- Braxton Berrios WR0.3%
- British Brooks RB0.3%
Projected Buffalo Bills Boxscore
Projected Houston Texans Boxscore
Buffalo Bills vs. Houston Texans: Game Breakdown
Matchup details
- Teams: Buffalo Bills vs. Houston Texans
- Date: loading...
- Time: loading...
Betting insights
Spread: Houston Texans favored at -4.62. Total: 43.29.
Game prediction summary
Buffalo Bills and Houston Texans face off on loading..., loading..., in a matchup that's drawn attention from bettors and fans alike.
We're projecting a final score of Buffalo Bills 24 – 19 Houston Texans, with win probabilities leaning 68% in favor of Buffalo Bills. Current odds list the spread at -4.62, with the total set at 43.29.
Touchdown Scorer Predictions
For Anytime Touchdown Scorer bets, the top option from Buffalo Bills is James Cook (the player with the highest anytime touchdown probability on the team at 51.8%). He is followed by Josh Allen, who also poses a strong scoring threat with a 49.7% chance.
On the Houston Texans side, Woody Marks leads with the highest probability at 42.7% , while Nico Collins follows closely at 36.9% .
For First Touchdown Scorer odds, our data again puts James Cook (team-high 11.2% probability) as the most likely to score first for Buffalo Bills. Over on the Houston Texans side, Woody Marks ranks highest with a 9.9% chance to be the first touchdown scorer in the game.
Box Score Predictions
When box score data is available, we spotlight each team's leaders by projection. For Buffalo Bills, James Cook (highest projected rusher on Buffalo Bills) is forecast for 80 rushing yards and 0.52 TDs , while Khalil Shakir (highest projected receiver on Buffalo Bills) is pegged for 50 receiving yards and 0.27 TDs .
On Houston Texans, Woody Marks (highest projected rusher on Houston Texans) leads the ground game with 64 yards and 0.43 TDs , and Nico Collins (highest projected receiver on Houston Texans) tops the passing attack with 76 yards and 0.37 TDs .
All stat lines are simulation-driven and update as new information becomes available.
Responsible betting
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