Arizona Cardinals vs San Francisco 49ers - NFL Prediction (2025-09-21)

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Arizona Cardinals
vs
San Francisco 49ers

Win probabilities

Arizona Cardinals
40%
San Francisco 49ers
60%

Predicted score

21 - 24
Spread (Team 1 - Team 2): -2.51
Projected total: 44.85

Fair odds (decimal)

Arizona Cardinals: 2.50
San Francisco 49ers: 1.67

Canadian Moneyline Odds

Arizona Cardinals
+125
San Francisco 49ers
-154
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Anytime Touchdown Probability

Arizona Cardinals
  • James Conner RB49.5%
  • Marvin Harrison WR34.2%
  • Trey McBride TE30.8%
  • Kyler Murray QB23.6%
  • Trey Benson RB19.5%
  • Michael Wilson WR16.9%
  • Elijah Higgins TE6.3%
  • Greg Dortch WR5.5%
  • Tip Reiman TE5.0%
  • Zay Jones WR2.8%
  • Emari Demercado RB1.5%
San Francisco 49ers
  • Christian McCaffrey RB61.0%
  • Jauan Jennings WR31.4%
  • Ricky Pearsall WR29.8%
  • Brian Robinson RB26.4%
  • Jake Tonges TE18.3%
  • Kendrick Bourne WR14.9%
  • Luke Farrell TE8.7%
  • Mac Jones QB6.6%
  • Kyle Juszczyk FB3.8%
  • Isaac Guerendo RB2.3%
  • Russell Gage WR1.8%
  • Marquez Valdes-Scantling WR1.6%
  • Skyy Moore WR0.7%
  • Jordan James RB0.7%

First Touchdown Probability

Arizona Cardinals
  • James Conner RB13.0%
  • Marvin Harrison WR8.0%
  • Trey McBride TE7.0%
  • Kyler Murray QB5.1%
  • Trey Benson RB4.1%
  • Michael Wilson WR3.5%
  • Elijah Higgins TE1.2%
  • Greg Dortch WR1.1%
  • Tip Reiman TE1.0%
  • Zay Jones WR0.5%
  • Emari Demercado RB0.3%
San Francisco 49ers
  • Christian McCaffrey RB17.8%
  • Jauan Jennings WR7.1%
  • Ricky Pearsall WR6.7%
  • Brian Robinson RB5.8%
  • Jake Tonges TE3.8%
  • Kendrick Bourne WR3.1%
  • Luke Farrell TE1.7%
  • Mac Jones QB1.3%
  • Kyle Juszczyk FB0.7%
  • Isaac Guerendo RB0.4%
  • Russell Gage WR0.3%
  • Marquez Valdes-Scantling WR0.3%
  • Skyy Moore WR0.1%
  • Jordan James RB0.1%

Projected Arizona Cardinals Boxscore

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Projected San Francisco 49ers Boxscore

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Arizona Cardinals vs. San Francisco 49ers: Game Breakdown

Matchup details

  • Teams: Arizona Cardinals vs. San Francisco 49ers
  • Date: loading...
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Betting insights

Spread: Arizona Cardinals favored at -2.51. Total: 44.85.

Game prediction summary

Arizona Cardinals and San Francisco 49ers face off on loading..., loading..., in a matchup that's drawn attention from bettors and fans alike.

We're projecting a final score of Arizona Cardinals 21 – 24 San Francisco 49ers, with win probabilities leaning 60% in favor of San Francisco 49ers. Current odds list the spread at -2.51, with the total set at 44.85.

Touchdown Scorer Predictions

For Anytime Touchdown Scorer bets, the top option from Arizona Cardinals is James Conner (the player with the highest anytime touchdown probability on the team at 49.5%). He is followed by Marvin Harrison, who also poses a strong scoring threat with a 34.2% chance.

On the San Francisco 49ers side, Christian McCaffrey leads with the highest probability at 61.0% , while Jauan Jennings follows closely at 31.4% .

For First Touchdown Scorer odds, our data again puts James Conner (team-high 13.0% probability) as the most likely to score first for Arizona Cardinals. Over on the San Francisco 49ers side, Christian McCaffrey ranks highest with a 17.8% chance to be the first touchdown scorer in the game.

Box Score Predictions

When box score data is available, we spotlight each team's leaders by projection. For Arizona Cardinals, James Conner (highest projected rusher on Arizona Cardinals) is forecast for 55 rushing yards and 0.49 TDs , while Trey McBride (highest projected receiver on Arizona Cardinals) is pegged for 64 receiving yards and 0.31 TDs .

On San Francisco 49ers, Christian McCaffrey (highest projected rusher on San Francisco 49ers) leads the ground game with 84 yards and 0.61 TDs , and Jauan Jennings (highest projected receiver on San Francisco 49ers) tops the passing attack with 62 yards and 0.31 TDs .

All stat lines are simulation-driven and update as new information becomes available.

Responsible betting

Sports betting should always be fun - a form of entertainment, not a way to solve financial problems. If you're finding that betting is causing stress or impacting your budget, take a step back. Never wager more than you can afford to lose.

Your mental well-being matters. Chasing losses or trying to "win it all back" is a warning sign. If friends or family raise concerns, take them seriously - they're often the first to notice when something's wrong.

If betting no longer feels like a choice or if it's affecting your life in a negative way, help is available. Visit Gambling Therapy for free, confidential support. Their trained advisors are available 24/7, and you'll also find peer support groups to talk with others who understand what you're going through.

Bet smart. Stay in control. Your well-being comes first.

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