Arizona Cardinals vs Indianapolis Colts - NFL Prediction (2025-10-12)

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Arizona Cardinals
vs
Indianapolis Colts

Win probabilities

Arizona Cardinals
25%
Indianapolis Colts
75%

Predicted score

20 - 27
Spread (Team 1 - Team 2): -7.28
Projected total: 46.58

Fair odds (decimal)

Arizona Cardinals: 4.00
Indianapolis Colts: 1.33

Canadian Moneyline Odds

Arizona Cardinals
+280
Indianapolis Colts
-370
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Anytime Touchdown Probability

Arizona Cardinals
  • Michael Carter RB34.7%
  • Marvin Harrison WR31.3%
  • Trey McBride TE26.4%
  • Kyler Murray QB20.2%
  • Emari Demercado RB19.0%
  • Michael Wilson WR17.7%
  • Bam Knight RB16.7%
  • Greg Dortch WR12.2%
  • Zay Jones WR10.8%
  • Elijah Higgins TE7.7%
Indianapolis Colts
  • Jonathan Taylor RB61.1%
  • Tyler Warren TE30.7%
  • Michael Pittman WR30.2%
  • Daniel Jones QB29.7%
  • Josh Downs WR20.8%
  • Alec Pierce WR20.0%
  • DJ Giddens RB11.2%
  • Adonai Mitchell WR10.4%
  • Ashton Dulin WR9.0%
  • Tyler Goodson RB5.7%
  • Drew Ogletree TE5.0%
  • Mo Alie-Cox TE4.8%
  • Anthony Gould WR4.7%
  • Will Mallory TE2.7%

First Touchdown Probability

Arizona Cardinals
  • Michael Carter RB7.6%
  • Marvin Harrison WR6.7%
  • Trey McBride TE5.5%
  • Kyler Murray QB4.0%
  • Emari Demercado RB3.8%
  • Michael Wilson WR3.5%
  • Bam Knight RB3.3%
  • Greg Dortch WR2.3%
  • Zay Jones WR2.0%
  • Elijah Higgins TE1.4%
Indianapolis Colts
  • Jonathan Taylor RB16.7%
  • Tyler Warren TE6.5%
  • Michael Pittman WR6.3%
  • Daniel Jones QB6.2%
  • Josh Downs WR4.1%
  • Alec Pierce WR3.9%
  • DJ Giddens RB2.1%
  • Adonai Mitchell WR1.9%
  • Ashton Dulin WR1.7%
  • Tyler Goodson RB1.0%
  • Drew Ogletree TE0.9%
  • Mo Alie-Cox TE0.9%
  • Anthony Gould WR0.9%
  • Will Mallory TE0.5%

Projected Arizona Cardinals Boxscore

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Projected Indianapolis Colts Boxscore

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Arizona Cardinals vs. Indianapolis Colts: Game Breakdown

Matchup details

  • Teams: Arizona Cardinals vs. Indianapolis Colts
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Betting insights

Spread: Arizona Cardinals favored at -7.28. Total: 46.58.

Game prediction summary

Arizona Cardinals and Indianapolis Colts face off on loading..., loading..., in a matchup that's drawn attention from bettors and fans alike.

We're projecting a final score of Arizona Cardinals 20 – 27 Indianapolis Colts, with win probabilities leaning 75% in favor of Indianapolis Colts. Current odds list the spread at -7.28, with the total set at 46.58.

Touchdown Scorer Predictions

For Anytime Touchdown Scorer bets, the top option from Arizona Cardinals is Michael Carter (the player with the highest anytime touchdown probability on the team at 34.7%). He is followed by Marvin Harrison, who also poses a strong scoring threat with a 31.3% chance.

On the Indianapolis Colts side, Jonathan Taylor leads with the highest probability at 61.1% , while Tyler Warren follows closely at 30.7% .

For First Touchdown Scorer odds, our data again puts Michael Carter (team-high 7.6% probability) as the most likely to score first for Arizona Cardinals. Over on the Indianapolis Colts side, Jonathan Taylor ranks highest with a 16.7% chance to be the first touchdown scorer in the game.

Box Score Predictions

When box score data is available, we spotlight each team's leaders by projection. For Arizona Cardinals, Michael Carter (highest projected rusher on Arizona Cardinals) is forecast for 54 rushing yards and 0.35 TDs , while Trey McBride (highest projected receiver on Arizona Cardinals) is pegged for 60 receiving yards and 0.26 TDs .

On Indianapolis Colts, Jonathan Taylor (highest projected rusher on Indianapolis Colts) leads the ground game with 88 yards and 0.61 TDs , and Michael Pittman (highest projected receiver on Indianapolis Colts) tops the passing attack with 59 yards and 0.30 TDs .

All stat lines are simulation-driven and update as new information becomes available.

Responsible betting

Sports betting should always be fun - a form of entertainment, not a way to solve financial problems. If you're finding that betting is causing stress or impacting your budget, take a step back. Never wager more than you can afford to lose.

Your mental well-being matters. Chasing losses or trying to "win it all back" is a warning sign. If friends or family raise concerns, take them seriously - they're often the first to notice when something's wrong.

If betting no longer feels like a choice or if it's affecting your life in a negative way, help is available. Visit Gambling Therapy for free, confidential support. Their trained advisors are available 24/7, and you'll also find peer support groups to talk with others who understand what you're going through.

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