Carolina Panthers vs San Francisco 49ers - NFL Prediction (2025-11-25)

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Carolina Panthers
vs
San Francisco 49ers

Win probabilities

Carolina Panthers
26%
San Francisco 49ers
74%

Predicted score

21 - 28
Spread (Team 1 - Team 2): -7.16
Projected total: 48.92

Fair odds (decimal)

Carolina Panthers: 3.85
San Francisco 49ers: 1.35

Canadian Moneyline Odds

Carolina Panthers
+270
San Francisco 49ers
-357
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Anytime Touchdown Probability

Carolina Panthers
  • Rico Dowdle RB49.0%
  • Tetairoa McMillan WR35.0%
  • Xavier Legette WR20.9%
  • Jalen Coker WR18.2%
  • Ja'Tavion Sanders TE14.8%
  • Chuba Hubbard RB12.6%
  • Bryce Young QB12.5%
  • Tommy Tremble TE10.5%
  • Jimmy Horn WR6.2%
  • Mitchell Evans TE5.7%
  • Brycen Tremayne WR5.5%
  • Hunter Renfrow WR3.1%
  • Trevor Etienne RB3.0%
San Francisco 49ers
  • Christian McCaffrey RB69.9%
  • George Kittle TE41.3%
  • Jauan Jennings WR31.2%
  • Ricky Pearsall WR29.2%
  • Brock Purdy QB16.5%
  • Brian Robinson RB14.7%
  • Kendrick Bourne WR9.9%
  • Kyle Juszczyk FB8.2%
  • Demarcus Robinson WR7.4%
  • Jake Tonges TE7.0%
  • Jordan James RB4.9%
  • Skyy Moore WR4.7%
  • Jordan Watkins WR4.5%
  • Luke Farrell TE3.8%
  • Isaac Guerendo RB3.3%

First Touchdown Probability

Carolina Panthers
  • Rico Dowdle RB11.6%
  • Tetairoa McMillan WR7.4%
  • Xavier Legette WR4.0%
  • Jalen Coker WR3.5%
  • Ja'Tavion Sanders TE2.8%
  • Chuba Hubbard RB2.3%
  • Bryce Young QB2.3%
  • Tommy Tremble TE1.9%
  • Jimmy Horn WR1.1%
  • Mitchell Evans TE1.0%
  • Brycen Tremayne WR1.0%
  • Hunter Renfrow WR0.5%
  • Trevor Etienne RB0.5%
San Francisco 49ers
  • Christian McCaffrey RB19.4%
  • George Kittle TE8.6%
  • Jauan Jennings WR6.1%
  • Ricky Pearsall WR5.6%
  • Brock Purdy QB2.9%
  • Brian Robinson RB2.6%
  • Kendrick Bourne WR1.7%
  • Kyle Juszczyk FB1.4%
  • Demarcus Robinson WR1.2%
  • Jake Tonges TE1.2%
  • Jordan James RB0.8%
  • Skyy Moore WR0.8%
  • Jordan Watkins WR0.7%
  • Luke Farrell TE0.6%
  • Isaac Guerendo RB0.5%

Projected Carolina Panthers Boxscore

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Projected San Francisco 49ers Boxscore

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Carolina Panthers vs. San Francisco 49ers: Game Breakdown

Matchup details

  • Teams: Carolina Panthers vs. San Francisco 49ers
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Betting insights

Spread: Carolina Panthers favored at -7.16. Total: 48.92.

Game prediction summary

Carolina Panthers and San Francisco 49ers face off on loading..., loading..., in a matchup that's drawn attention from bettors and fans alike.

We're projecting a final score of Carolina Panthers 21 – 28 San Francisco 49ers, with win probabilities leaning 74% in favor of San Francisco 49ers. Current odds list the spread at -7.16, with the total set at 48.92.

Touchdown Scorer Predictions

For Anytime Touchdown Scorer bets, the top option from Carolina Panthers is Rico Dowdle (the player with the highest anytime touchdown probability on the team at 49.0%). He is followed by Tetairoa McMillan, who also poses a strong scoring threat with a 35.0% chance.

On the San Francisco 49ers side, Christian McCaffrey leads with the highest probability at 69.9% , while George Kittle follows closely at 41.3% .

For First Touchdown Scorer odds, our data again puts Rico Dowdle (team-high 11.6% probability) as the most likely to score first for Carolina Panthers. Over on the San Francisco 49ers side, Christian McCaffrey ranks highest with a 19.4% chance to be the first touchdown scorer in the game.

Box Score Predictions

When box score data is available, we spotlight each team's leaders by projection. For Carolina Panthers, Rico Dowdle (highest projected rusher on Carolina Panthers) is forecast for 78 rushing yards and 0.49 TDs , while Tetairoa McMillan (highest projected receiver on Carolina Panthers) is pegged for 65 receiving yards and 0.35 TDs .

On San Francisco 49ers, Christian McCaffrey (highest projected rusher on San Francisco 49ers) leads the ground game with 73 yards and 0.70 TDs , and George Kittle (highest projected receiver on San Francisco 49ers) tops the passing attack with 57 yards and 0.41 TDs .

All stat lines are simulation-driven and update as new information becomes available.

Responsible betting

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Your mental well-being matters. Chasing losses or trying to "win it all back" is a warning sign. If friends or family raise concerns, take them seriously - they're often the first to notice when something's wrong.

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