Buffalo Bills vs Houston Texans - NFL Prediction (2025-11-21)

Kickoff: loading... Starting soon
Buffalo Bills
vs
Houston Texans

Win probabilities

Buffalo Bills
68%
Houston Texans
32%

Predicted score

24 - 19
Spread (Team 1 - Team 2): 4.62
Projected total: 43.29

Fair odds (decimal)

Buffalo Bills: 1.47
Houston Texans: 3.13

Canadian Moneyline Odds

Buffalo Bills
-278
Houston Texans
+215
Visit site

Anytime Touchdown Probability

Buffalo Bills
  • James Cook RB51.0%
  • Josh Allen QB49.4%
  • Khalil Shakir WR27.1%
  • Dawson Knox TE21.3%
  • Keon Coleman WR18.5%
  • Ty Johnson RB17.9%
  • Gabe Davis WR17.2%
  • Tyrell Shavers WR16.9%
  • Joshua Palmer WR14.8%
  • Elijah Moore WR9.5%
  • Jackson Hawes TE9.4%
  • Ray Davis RB5.3%
Houston Texans
  • Woody Marks RB42.5%
  • Nico Collins WR36.5%
  • Dalton Schultz TE19.6%
  • Jayden Higgins WR17.7%
  • Nick Chubb RB16.8%
  • Christian Kirk WR11.5%
  • Xavier Hutchinson WR9.0%
  • Davis Mills QB8.7%
  • Jaylin Noel WR7.5%
  • Cade Stover TE5.5%
  • Dare Ogunbowale RB3.6%
  • Dameon Pierce RB2.5%
  • Braxton Berrios WR2.1%
  • British Brooks RB2.0%

First Touchdown Probability

Buffalo Bills
  • James Cook RB11.5%
  • Josh Allen QB11.0%
  • Khalil Shakir WR5.1%
  • Dawson Knox TE3.9%
  • Keon Coleman WR3.3%
  • Ty Johnson RB3.2%
  • Gabe Davis WR3.1%
  • Tyrell Shavers WR3.0%
  • Joshua Palmer WR2.6%
  • Elijah Moore WR1.6%
  • Jackson Hawes TE1.6%
  • Ray Davis RB0.9%
Houston Texans
  • Woody Marks RB9.9%
  • Nico Collins WR8.1%
  • Dalton Schultz TE3.9%
  • Jayden Higgins WR3.5%
  • Nick Chubb RB3.3%
  • Christian Kirk WR2.2%
  • Xavier Hutchinson WR1.7%
  • Davis Mills QB1.6%
  • Jaylin Noel WR1.4%
  • Cade Stover TE1.0%
  • Dare Ogunbowale RB0.7%
  • Dameon Pierce RB0.4%
  • Braxton Berrios WR0.4%
  • British Brooks RB0.4%

Projected Buffalo Bills Boxscore

Sort by:

Projected Houston Texans Boxscore

Sort by:

Buffalo Bills vs. Houston Texans: Game Breakdown

Matchup details

  • Teams: Buffalo Bills vs. Houston Texans
  • Date: loading...
  • Time: loading...

Betting insights

Spread: Houston Texans favored at -4.62. Total: 43.29.

Game prediction summary

Buffalo Bills and Houston Texans face off on loading..., loading..., in a matchup that's drawn attention from bettors and fans alike.

We're projecting a final score of Buffalo Bills 24 – 19 Houston Texans, with win probabilities leaning 68% in favor of Buffalo Bills. Current odds list the spread at -4.62, with the total set at 43.29.

Touchdown Scorer Predictions

For Anytime Touchdown Scorer bets, the top option from Buffalo Bills is James Cook (the player with the highest anytime touchdown probability on the team at 51.0%). He is followed by Josh Allen, who also poses a strong scoring threat with a 49.4% chance.

On the Houston Texans side, Woody Marks leads with the highest probability at 42.5% , while Nico Collins follows closely at 36.5% .

For First Touchdown Scorer odds, our data again puts James Cook (team-high 11.5% probability) as the most likely to score first for Buffalo Bills. Over on the Houston Texans side, Woody Marks ranks highest with a 9.9% chance to be the first touchdown scorer in the game.

Box Score Predictions

When box score data is available, we spotlight each team's leaders by projection. For Buffalo Bills, James Cook (highest projected rusher on Buffalo Bills) is forecast for 82 rushing yards and 0.52 TDs , while Khalil Shakir (highest projected receiver on Buffalo Bills) is pegged for 49 receiving yards and 0.27 TDs .

On Houston Texans, Woody Marks (highest projected rusher on Houston Texans) leads the ground game with 66 yards and 0.43 TDs , and Nico Collins (highest projected receiver on Houston Texans) tops the passing attack with 75 yards and 0.37 TDs .

All stat lines are simulation-driven and update as new information becomes available.

Responsible betting

Sports betting should always be fun - a form of entertainment, not a way to solve financial problems. If you're finding that betting is causing stress or impacting your budget, take a step back. Never wager more than you can afford to lose.

Your mental well-being matters. Chasing losses or trying to "win it all back" is a warning sign. If friends or family raise concerns, take them seriously - they're often the first to notice when something's wrong.

If betting no longer feels like a choice or if it's affecting your life in a negative way, help is available. Visit Gambling Therapy for free, confidential support. Their trained advisors are available 24/7, and you'll also find peer support groups to talk with others who understand what you're going through.

Bet smart. Stay in control. Your well-being comes first.

Back to all games