Indianapolis Colts vs Los Angeles Rams - NFL Prediction (2025-09-28)

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Indianapolis Colts
vs
Los Angeles Rams

Win probabilities

Indianapolis Colts
29%
Los Angeles Rams
71%

Predicted score

20 - 26
Spread (Team 1 - Team 2): -5.72
Projected total: 46.09

Fair odds (decimal)

Indianapolis Colts: 3.45
Los Angeles Rams: 1.41

Canadian Moneyline Odds

Indianapolis Colts
+187
Los Angeles Rams
-238
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Indianapolis Colts vs. Los Angeles Rams: Game Breakdown

Matchup details

  • Teams: Indianapolis Colts vs. Los Angeles Rams
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Betting insights

Spread: Indianapolis Colts favored at -5.72. Total: 46.09.

Game prediction summary

Indianapolis Colts and Los Angeles Rams face off on loading..., loading..., in a matchup that's drawn attention from bettors and fans alike.

We're projecting a final score of Indianapolis Colts 20 – 26 Los Angeles Rams, with win probabilities leaning 71% in favor of Los Angeles Rams. Current odds list the spread at -5.72, with the total set at 46.09.

Responsible betting

Sports betting should always be fun - a form of entertainment, not a way to solve financial problems. If you're finding that betting is causing stress or impacting your budget, take a step back. Never wager more than you can afford to lose.

Your mental well-being matters. Chasing losses or trying to "win it all back" is a warning sign. If friends or family raise concerns, take them seriously - they're often the first to notice when something's wrong.

If betting no longer feels like a choice or if it's affecting your life in a negative way, help is available. Visit Gambling Therapy for free, confidential support. Their trained advisors are available 24/7, and you'll also find peer support groups to talk with others who understand what you're going through.

Bet smart. Stay in control. Your well-being comes first.

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