Denver Broncos vs Los Angeles Chargers - NFL Prediction (2025-09-21)

Denver Broncos vs. Los Angeles Chargers: Game Breakdown

Matchup details

• Teams: Denver Broncos vs. Los Angeles Chargers
• Date: loading...
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Betting insights

Spread: Denver Broncos favored at -2.35. Total: 45.99.

Game prediction summary

Denver Broncos and Los Angeles Chargers face off on loading..., loading..., in a matchup that's drawn attention from bettors and fans alike.

We're projecting a final score of Denver Broncos 22 – 24 Los Angeles Chargers, with win probabilities leaning 59% in favor of Los Angeles Chargers. Current odds list the spread at -2.35, with the total set at 45.99.

Touchdown Scorer Predictions

For Anytime Touchdown Scorer bets, the top option from Denver Broncos is J.K. Dobbins (the player with the highest anytime touchdown probability on the team at 44.2%). He is followed by Courtland Sutton, who also poses a strong scoring threat with a 32.6% chance.

On the Los Angeles Chargers side, Omarion Hampton leads with the highest probability at 44.9% , while Ladd McConkey follows closely at 34.2% .

For First Touchdown Scorer odds, our data again puts J.K. Dobbins (team-high 9.4% probability) as the most likely to score first for Denver Broncos. Over on the Los Angeles Chargers side, Omarion Hampton ranks highest with a 11.3% chance to be the first touchdown scorer in the game.

Box Score Predictions

When box score data is available, we spotlight each team's leaders by projection. For Denver Broncos, J.K. Dobbins (highest projected rusher on Denver Broncos) is forecast for 58 rushing yards and 0.44 TDs , while Courtland Sutton (highest projected receiver on Denver Broncos) is pegged for 60 receiving yards and 0.33 TDs .

On Los Angeles Chargers, Omarion Hampton (highest projected rusher on Los Angeles Chargers) leads the ground game with 48 yards and 0.45 TDs , and Ladd McConkey (highest projected receiver on Los Angeles Chargers) tops the passing attack with 64 yards and 0.34 TDs .

All stat lines are simulation-driven and update as new information becomes available.

Responsible betting

Sports betting should always be fun - a form of entertainment, not a way to solve financial problems. If you're finding that betting is causing stress or impacting your budget, take a step back. Never wager more than you can afford to lose.

Your mental well-being matters. Chasing losses or trying to "win it all back" is a warning sign. If friends or family raise concerns, take them seriously - they're often the first to notice when something's wrong.

If betting no longer feels like a choice or if it's affecting your life in a negative way, help is available. Visit Gambling Therapy for free, confidential support. Their trained advisors are available 24/7, and you'll also find peer support groups to talk with others who understand what you're going through.

Bet smart. Stay in control. Your well-being comes first.