Los Angeles Rams vs Philadelphia Eagles - NFL Prediction (2025-09-21)

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Los Angeles Rams
vs
Philadelphia Eagles

Win probabilities

Los Angeles Rams
39%
Philadelphia Eagles
61%

Predicted score

21 - 24
Spread (Team 1 - Team 2): -2.89
Projected total: 44.87

Fair odds (decimal)

Los Angeles Rams: 2.56
Philadelphia Eagles: 1.64

Canadian Moneyline Odds

Los Angeles Rams
Philadelphia Eagles

Anytime Touchdown Probability

Los Angeles Rams
  • Kyren Williams RB52.7%
  • Davante Adams WR37.8%
  • Puka Nacua WR36.2%
  • Tyler Higbee TE17.8%
  • Blake Corum RB13.6%
  • Tutu Atwell WR9.2%
  • Jordan Whittington WR8.5%
  • Davis Allen TE7.4%
  • Matthew Stafford QB6.0%
  • Xavier Smith WR3.8%
  • Terrance Ferguson TE3.5%
  • Colby Parkinson TE3.3%
  • Jarquez Hunter RB3.2%
Philadelphia Eagles
  • Saquon Barkley RB56.3%
  • Jalen Hurts QB55.6%
  • A.J. Brown WR31.3%
  • DeVonta Smith WR27.9%
  • Dallas Goedert TE19.8%
  • Grant Calcaterra TE12.1%
  • Jahan Dotson WR10.7%
  • Will Shipley RB9.7%
  • Kylen Granson TE5.1%
  • AJ Dillon RB4.9%
  • John Metchie WR4.2%
  • Tank Bigsby RB1.9%

First Touchdown Probability

Los Angeles Rams
  • Kyren Williams RB12.7%
  • Davante Adams WR8.1%
  • Puka Nacua WR7.6%
  • Tyler Higbee TE3.3%
  • Blake Corum RB2.5%
  • Tutu Atwell WR1.6%
  • Jordan Whittington WR1.5%
  • Davis Allen TE1.3%
  • Matthew Stafford QB1.0%
  • Xavier Smith WR0.7%
  • Terrance Ferguson TE0.6%
  • Colby Parkinson TE0.6%
  • Jarquez Hunter RB0.6%
Philadelphia Eagles
  • Saquon Barkley RB13.4%
  • Jalen Hurts QB13.1%
  • A.J. Brown WR6.0%
  • DeVonta Smith WR5.3%
  • Dallas Goedert TE3.6%
  • Grant Calcaterra TE2.1%
  • Jahan Dotson WR1.8%
  • Will Shipley RB1.6%
  • Kylen Granson TE0.8%
  • AJ Dillon RB0.8%
  • John Metchie WR0.7%
  • Tank Bigsby RB0.3%

Projected Los Angeles Rams Boxscore

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Projected Philadelphia Eagles Boxscore

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Los Angeles Rams vs. Philadelphia Eagles: Game Breakdown

Matchup details

  • Teams: Los Angeles Rams vs. Philadelphia Eagles
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Betting insights

Spread: Los Angeles Rams favored at -2.89. Total: 44.87.

Game prediction summary

Los Angeles Rams and Philadelphia Eagles face off on loading..., loading..., in a matchup that's drawn attention from bettors and fans alike.

We're projecting a final score of Los Angeles Rams 21 – 24 Philadelphia Eagles, with win probabilities leaning 61% in favor of Philadelphia Eagles. Current odds list the spread at -2.89, with the total set at 44.87.

Touchdown Scorer Predictions

For Anytime Touchdown Scorer bets, the top option from Los Angeles Rams is Kyren Williams (the player with the highest anytime touchdown probability on the team at 52.7%). He is followed by Davante Adams, who also poses a strong scoring threat with a 37.8% chance.

On the Philadelphia Eagles side, Saquon Barkley leads with the highest probability at 56.3% , while Jalen Hurts follows closely at 55.6% .

For First Touchdown Scorer odds, our data again puts Kyren Williams (team-high 12.7% probability) as the most likely to score first for Los Angeles Rams. Over on the Philadelphia Eagles side, Saquon Barkley ranks highest with a 13.4% chance to be the first touchdown scorer in the game.

Box Score Predictions

When box score data is available, we spotlight each team's leaders by projection. For Los Angeles Rams, Kyren Williams (highest projected rusher on Los Angeles Rams) is forecast for 72 rushing yards and 0.53 TDs , while Puka Nacua (highest projected receiver on Los Angeles Rams) is pegged for 80 receiving yards and 0.36 TDs .

On Philadelphia Eagles, Saquon Barkley (highest projected rusher on Philadelphia Eagles) leads the ground game with 91 yards and 0.56 TDs , and A.J. Brown (highest projected receiver on Philadelphia Eagles) tops the passing attack with 63 yards and 0.31 TDs .

All stat lines are simulation-driven and update as new information becomes available.

Responsible betting

Sports betting should always be fun - a form of entertainment, not a way to solve financial problems. If you're finding that betting is causing stress or impacting your budget, take a step back. Never wager more than you can afford to lose.

Your mental well-being matters. Chasing losses or trying to "win it all back" is a warning sign. If friends or family raise concerns, take them seriously - they're often the first to notice when something's wrong.

If betting no longer feels like a choice or if it's affecting your life in a negative way, help is available. Visit Gambling Therapy for free, confidential support. Their trained advisors are available 24/7, and you'll also find peer support groups to talk with others who understand what you're going through.

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